General Info:

Leucovorin is used to treat or prevent serious blood cell disorders (such as thrombocytopenia, neutropenia, anemia) caused by certain drugs (folic acid antagonists such as methotrexate, trimethoprim, pyrimethamine).

Leucovorin is a form of folic acid. Folic acid helps your body produce and maintain new cells, and also helps prevent changes to DNA that may lead to cancer. Folic acid is present in many foods such as dried beans, peas, oranges, spinach, and others.

Leucovorin is used to reduce the side effects of large doses or accidental overdose of medications that can reduce the effects of folic acid in the body. This includes methotrexate (Rheumatrex), pyrimethamine (Daraprim), trimethoprim (Trimpex, Proloprim), and others.

Leucovorin may also be used to treat anemia (lack of red blood cells) caused by chemotherapy.

Leucovorin may also be used for purposes other than those listed in this medication guide.

Do not take leucovorin if you have anemia that is caused by a lack of vitamin B12.

Leucovorin is sold as brand names:

• Leucovorin Calcium